Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p215 | (1) | WCRB2014

Detection of potassium channel defects in ICSI patients by patch clamp electrophysiology

Brown Sean G , Mansell Steven , Williams Hannah , da Silva Sarah Martins , Publicover Stephen , Wilson Stuart , Barratt Christopher

Introduction: Potassium channels are essential for the physiological regulation of cell excitability through control of membrane hyperpolarisation. In human sperm slo1 and/or 3 have been proposed to mediate this function (Mannowetz et al. 2013, Mansell et al. 2014). However, to date there is no information on dysfunction in men and the consequence of this for their fertility.Materials and methods: Men undergoing ICSI treatment or recall...